Sclerostin antibody stimulates bone regeneration after experimental periodontitis
نویسندگان
چکیده
منابع مشابه
Sclerostin antibody stimulates bone regeneration after experimental periodontitis.
The reconstruction of large osseous defects due to periodontitis is a challenge in regenerative therapy. Sclerostin, secreted by osteocytes, is a key physiological inhibitor of osteogenesis. Pharmacologic inhibition of sclerostin using sclerostin-neutralizing monoclonal antibody (Scl-Ab) thus increases bone formation, bone mass and bone strength in models of osteopenia and fracture repair. This...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2013
ISSN: 0884-0431
DOI: 10.1002/jbmr.1984